The number of kittens a cat can have in a litter can vary based on several factors including the cat's breed, age, health, and genetics. On average, a cat can have anywhere from one to nine kittens in a litter, but it's most common for a litter to consist of about three to five kittens. However, there have been cases where cats have had larger litters. It's also worth noting that the size of the litter may decrease as the cat ages. Consulting with a veterinarian can provide more specific information based on individual circumstances.