A standard bottle of wine in the US contains around 25.4 fluid ounces (750 milliliters).
Here's a breakdown:

Standard bottle size: Most wine bottles follow a standard size of 750 milliliters (mL). This is the volume measurement you'll typically see on a wine label.

Milliliters to ounces conversion: 1 milliliter (mL) is equal to 0.0338 fluid ounces (fl oz).

Calculating ounces in a bottle: To convert the standard 750 mL bottle size to ounces, we multiply the milliliters by the conversion factor:
750 mL * 0.0338 fl oz/mL = 25.35 fl oz (rounded to two decimal places)
For practical purposes, most people consider a standard wine bottle to hold 25.4 ounces.